DETAILS, FICTION AND LDN-27219 DRUG DEVELOPMENT PIPELINE

One particularly attention-grabbing compound is LDN-27219. Though most tTG inhibitors are built to bind on the protein crosslinking active web site, LDN-27219 as an alternative binds into the nucleotide binding pocket with the enzyme although it's in its shut-point out conformation, and stabilizes that conformation to forestall crosslinking activit